Genetic Testing & Genetic Counseling Services We offer comprehensive genetic testing services to diagnose and understand various neuropsychiatric and neurodevelopmental disorders. Our services include molecular diagnosis for conditions such as Duchenne muscular dystrophy, Huntington’s disease, and spinocerebellar ataxia. By providing accurate and timely genetic information, we support clinicians in making informed decisions about patient care and personalized treatment strategies. Who Will Benefit? Individuals suspected of having specific neurological or psychiatric illnesses, as determined by their treating specialist (neurologist or psychiatrist), will benefit from our services. ​ How to Get an Appointment Appointments can be made through the GCAT clinic, which operates on Saturdays in collaboration with Neurology and other services. An initial workup, including a neurological or psychiatric evaluation, is essential to determine the necessary tests. Tests Done HD SCA1, SCA2, SCA3, SCA12, SCA27B (SCA50) SMA DMD FRDA

Our Research Our research employs state-of-the-art technologies, including: Next-Generation Sequencing : For identifying genetic variations associated with mental health disorders. Linkage and Association Studies : To find correlations between genetic markers and psychiatric conditions. Molecular Psychiatry : Investigating biomarkers and molecular pathways to develop targeted treatments. ​ Neurogenetics : Studying the genetic and epigenetic factors contributing to neurological and psychiatric diseases List of Projects PARAM ABIGNET ENIGMA GenECT cVEDA DBT/Wellcome Trust IOG MQ DST-INSPIRE IBRO/Dana DNA Seq Post-mortem Brains Epigenetics SKAN PARAM The PARAM (Pathways to Resilience and Mental Health) project aims to understand how genetic and environmental factors influence brain development and mental health. Researchers will track brain development from the second trimester of pregnancy (-6 months) to 30 years of age, mapping the timeline for psychological and emotional abilities. With a sample size of over 10,000 participants, the study seeks to identify deviations in brain development that may increase vulnerability to brain disorders. Principal Investigator: Dr. Vivek Benegal Investigator(s): Dr.Eesha Sharma, Dr Bharath Holla, Dr Meera Purushottam, Dr.Meera S S, Dr.Jayant Mahadevan, Dr.Kuppan Gokula Krishnan, Dr Srinivas Bharath Supported By: Indian Council of Medical Research (ICMR) ABIGNET The Asian Bipolar Genetics Network (A-BIG-NET) is a study to understand the genetics of bipolar disorder in Asian populations. The project is recruiting participants from South Korea, Singapore, Taiwan, India, and Pakistan, with the goal of analyzing DNA from 27,500 individuals with Bipolar Disorder Type 1 (BP-I) and 16,000 without it. Utilizing data from 15,000 cases and 14,000 controls, this research aims to enhance the understanding of bipolar disorder and other mental health conditions such as schizophrenia, ultimately contributing to global mental health research and promoting healthcare equity. Principal Investigator: Dr Biju Viswanath (Indian cohort) Supported By: National Institute of Mental Health (NIMH) of the National Institute of Health (NIH), USA Collaborators: Broad Institute, National Taiwan University, Virginia Commonwealth University and Johns Hopkins University ENIGMA The 'India ENIGMA Initiative for Global Aging and Mental Health' at NIMHANS, Bengaluru, with USC, aims to study brain aging biomarkers and dementia risk factors. It assesses healthy elders, Alzheimer’s patients, and Mild Cognitive Impairment (MCI) cases for psychosocial factors and biomarkers like genetics and brain imaging over two years. Using 'brain age' from MRI scans, it examines accelerated brain aging in dementia. The study seeks insights for preventive and treatment strategies for dementia in India Principal Investigator: Dr. Vivek Benegal Investigator(s): Dr John P John, Dr Venkatasubramanian Ganesan, Dr P. T. Sivakumar Dr. Y. C. Janardhan Reddy, Dr. Sanjeev Jain, Dr. Mathew Varghese, Dr. Vivek Benegal, Dr. Kandavel Thennarasu, Dr. Jitender Saini, Dr. Anish V. Cherian, Dr. Meera Purushottam, Dr. Preeti Sinha, Dr Biju Viswanath, Dr. Subashchandrabose Chinnathambi, Dr. Ravikesh Tripathi, Dr. Gokula Krishnan, Dr Reeteka Sud Supported By: National Institute of Aging (NIA), USA of the National Institute of Health (NIH), USA Collaborators: University of South California (USC), USA GenECT This study aims to investigate severe mood disorders and their response to electroconvulsive therapy (ECT) by collecting genetic material from individuals undergoing ECT treatment. Collaborating with the Psychiatric Genomics Consortium (PGC), the research will identify genetic factors associated with severe mood disorders and predict patient response to ECT. The goal is to understand the unique genetic makeup of these disorders and develop more effective treatment strategies. Conducted at Johns Hopkins ECT centers in collaboration with PGC worldwide, the study leverages clinical data to minimize patient and provider burden. Principal Investigator: Dr Biju Viswanath Investigator(s): Dr. Sanjeev Jain, Dr. Jagadisha Thirthalli Dr. Naren P Rao, Dr. Meera Purushottam, Dr. Reeteka Sud Supported By: National Institute of Mental Health (NIMH) of the National Institute of Health (NIH), USA cVEDA The Consortium on Vulnerability to Externalizing Disorders and Addictions (c-VEDA) project aims to understand how environmental and genetic factors in developed and developing countries influence brain function and behavior related to substance misuse and externalizing disorders. Through collaboration with Indian partners, the project will compare data from European and UK studies with Indian cohorts to identify risk factors and neurobehavioral trajectories for mental health research.The studies include mental health checks and genetic testing and also looks at brain scans and genes, aiming to understand how culture influences behavior and brain development. Principal Investigator: Dr Vivek Benegal, Dr Eesha Sharma, Dr Bharath Holla, Dr Meera Purushottam Supported By: Indian Council for Medical Research (ICMR), Newton Grant from the Medical Research Council (MRC), United Kingdom Collaborators: Professor Gunter Schumann, King’s College London, UK SKAN: Effect of antipsychotics on the gut microbiome This project aims to assess any changes in the microbiome starting from the hospital admission till acute antipsychotic therapy administered as part of standard medical procedure. This will be useful to tackle bothersome side-effects of antipsychotics through simple interventions. Principal Investigator: Dr Sanjeev Jain, Dr Meera Purushottam Investigators: Prof YC Janardhan Reddy, Prof Mathew Varghese, Dr Biju Viswanath, Dr Suvarna Alladi, Prof PT Sivakumar, Prof Preeti Sinha, Dr Faheem Arshad SKAN: Genetics of bipolar disorder and related illnesses: a study of intermediate alleles in candidate genes with repeat expansion loci This study aims to assess the repeat size of simple repeat sequences at SCA1, 2, and 3, HTT, DRPLA, and C9ORF loci in severe mental illness (bipolar disorder) and compare them with controls. The need for this study arises from the possibility that severe mental illnesses like bipolar disorder may be part of an underlying neurodegenerative syndrome. By examining the frequency of intermediate and higher normal alleles at these loci, the study will provide insights into their prevalence and association with neuropsychiatric illness in our population. Principal Investigator: Dr Meera Purushottam Investigators: Dr Sanjeev Jain, Dr Biju Viswanath, Dr Ajit Dahale Deciphering the molecular mechanisms of lithium response in patients with bipolar disorder This study aims to investigate the unique aspects of bipolar disorder in Indian patients, focusing on symptoms and response to lithium treatment. Research correlations between mania prevalence, lithium response, and side effects like hypothyroidism and kidney disease. They also explore genetic risk assessment to predict lithium response and study brain development processes in non-responders to lithium treatment. Principal Investigator: Dr. Biju Viswanath Co-Principal Investigator: Dr. Venkatasubramanian Ganesan Supported By: DBT/Wellcome Trust India Alliance An informal, safe and supportive outreach approach to bridge the Mental Health Gap in India This project aims to bridge gaps by fostering safe, informal outreach about mental illnesses. The objective is to facilitate interactions among scientists, patients, caregivers, and clinicians through different activities. These include a mental health interview series (available digitally), outreach and public engagement events, competition and e-books & resources on mental health disorders. Principal Investigator: Dr Reeteka Sud, Dr Biju Viswanath Supported by: IndiaBioscience Outreach Grant Collaborators: Project Encephalon, Sangath India, BipolarIndia Genetic and environmental determinants of treatment emergent metabolic abnormalities in schizophrenia This study aims to explore how genetic and environmental factors affect metabolic side effects in schizophrenia patients treated with antipsychotics (risperidone or olanzapine). It looks at whether genetic risk scores for metabolic conditions can predict these side effects and how factors like age, sex, illness severity, medication, and lifestyle influence this relationship. The study also examines differences in these effects among different ancestries, especially in South Asian populations using the CLOZUK sample. Principal Investigator: Dr Suhas Ganesh Investigator(s): Dr Jagadisha Thirthalli, Dr Biju Viswanath, Dr Venkatsubramanian G, Dr Meera Purushottam Supported By: MQ - Transforming Mental Health, UK Collaborators: Dr Nishant Goyal (Central Institute of Psychiatry, India), Dr Basudeb Das (Central Institute of Psychiatry, India), Dr Naomi Wray (University of Queensland, Australia), Dr Patrick Sullivan (University of North Carolina, Chapel Hill, US), Dr James Walters (Cardiff University, UK) Investigating the immune dynamics of autism spectrum disorders The proposed project aims to enable the initiation of molecular research in neuro-immuno-genetics. The goal is to help identify molecular markers of inflammation in patients with autism spectrum disorders, which may lead to a prospective diagnostic tool Principal Investigator: Dr Ashitha S N M Supported by: DST-INSPIRE Faculty Grant Scheme Coffee, Cinema and Community: Redefining Mental Health A project to host city-wide science cafe events and movie screenings, and provide translated educational resources (in Hindi and Kannada) discussing mental health across Bangalore, India. Principal Investigator: Dr Reeteka Sud Co-Investigator(s): Dr Biju Viswanath, Anushka Banerjee, Kadambari Patil Supported by: IBRO/Dana Foundation Brain Awareness Week Grant Collaborators: Dr KS Meena Iyer (Mental Health Education Department, NIMHANS), Dr Ranjana Sarma (Centre for Brain and Mind - NCBS Sequencing of archived DNA: A Neurodegenerative study The project will involve performing whole exome sequencing of DNA samples of patients diagnosed with cerebellar ataxias (ADCAs/SCAs), neurodegenerative diseases, including early onset Parkinson's disease (PD), and frontotemporal dementia (FTD) in the Indian population. The study aims to identify predictive genetic and molecular markers for early detection of these neurodegenerative disorders, which can help improve diagnostics and identify targets for interventions and management. Principal Investigator: Dr Meera Purushottam Co-Principal Investigators: Dr Ramesh Hariharan, Dr Pramod Kumar Pal, Dr Biju Viswanath Co-Investigators: Dr Ravi Yadav, Dr Vikram Holla, Dr Nitish Kamble Post-mortem Brain Research Research focuses on genomics, transcriptomics, trinucleotide repeat analyses, and epigenetic investigations across brain regions. Epigenetic Research ​ DNA methylation levels in various psychiatric disorders( addiction, psychosis) and effect of stress and its effects are particular areas of interest. Differential expression of microRNAs upon drug exposure for example in vitro Lithium exposure to Bipolar Disorder patients derived Lymphoblastoid Cell lines (LCLs) are being investigated. Up

Coffee, Cinema and Community: Redefining Mental Health Brain Awareness Week aims to foster public enthusiasm and support for brain science through education and awareness. Our week long program, held from July 15th - 21st. 2024 included book talks, art exhibitions, film discussions and learning about the history of NIMHANS, encouraging Bengaluru residents to learn & talk about mental health and neuroscience research. ​July 15 | Tour of NIMHANS with the Director The tour offered an insightful experience, including a guided visit through various parts of NIMHANS to learn about its history and groundbreaking research, led by the Director of NIMHANS, Professor Pratima Murthy. High school students from Gopalan International School interacted with our scientists, engaged in activities and paid a visit to the renowned Brain Museum. ​July 17 | "Mindscape and Landscape: An Illustrated History of NIMHANS" by Dr. Sanjeev Jain, Emeritus Professor, NIMHANS At this insightful book talk, Dr. Sanjeev Jain, eminent psychiatrist and author, delved into the rich history of NIMHANS and provided a captivating overview of the institution's journey and its significant contributions to mental health research and care, as detailed in his book. ​July 20 | Through the Looking Glass: Artistic Perspectives on Mental Health ​Artists from all across India harnessed their artistic skills to express their feelings about mental health. Art and photographs were displayed at the Neurobiology Research Centre at NIMHANS, and visitors also got a chance to go home with postcards of the artwork. ​ You can view the artwork displayed at our exhibit on the right → (click to enlarge) Sophiya Sinha Charu Krishnaraju Vaishnavi S Naragunda Sophiya Sinha 1/51 ​July 20 | Mental Health & Movies - The Good, The Bad & The Ugly In this thought-provoking fireside chat on the representation of mental illnesses and health in movies our panellists comprising filmmakers (Vrinda Samartha, Suneel Raghavendra), mental health professionals (Dr Suhas Satish), and film bloggers (Dr Basundhara Ghosh) examined the impact of cinematic portrayals on public perception and stigma surrounding mental health issues, through a screening of clips from popular Indian films and engaging discussions with the audience. The talk was moderated by Anmol Tikoo. ​ The discussion will be available on YouTube soon. ​July 21 | Stories in Motion: Mental Wellness through Art and Narratives by Dr. Ankit Dwivedi Our participants experienced the power of storytelling in understanding mental health with Dr. Ankit Dwivedi, a professional storyteller and researcher. This interactive workshop explored the nuances of mental health using engaging storytelling and community building, helping participants gain a deeper appreciation for the human experiences behind mental health challenges. Brain Awareness Week is a global campaign aimed at increasing public awareness of the progress and benefits of brain research. This annual event unites the efforts of organisations worldwide in promoting the importance of brain health. This event was sponsored by the International Brain Research Organisation (IBRO) and Dana Foundation Brain Awareness Week Grant , in association with the Department of Mental Health Education, NIMHANS, Bengaluru and the Centre for Brain and Mind - National Centre for Biological Sciences (NCBS), Bengaluru . We thank our venue partners, the Bangalore International Centre and AttaGalatta . Coordinators: Anushka Banerjee & Kadambari Patil | Organisers: Dr Reeteka Sud, Dr Biju Viswanath, Dr YC Janardhan Reddy, Dr Meena KS, Dr Ranjana Sarma & Shatabdi Pal | Designer: Sukriti Chordiya

Contact Us Phone 080-2699-5263 Email molgen5263@gmail.com Social Media First Name Last Name Email Message Send Thanks for submitting!

सभी (18) General Pages (16) इवेंट्स (2) "" के लिए परिणाम मिले General Pages (16) Participate in our research @ MGL NIMHANS Participate in Our Research Be a part of our groundbreaking research initiatives by volunteering! Our research delves into understanding the complexities behind severe psychiatric illnesses. Our studies may involve - non-invasive methods like EEG recordings, where sensors are placed on the scalp to capture brainwave activity MRI brain scans simple measurements of button-press responses or eye movements blood sample which will be used for genetic and stem cell studies For more information about which studies are currently recruiting volunteers, click the project names to read about the work and go through the hyperlinked information & consent forms listed below. If you are eager to participate as a research volunteer, click the project you wish to volunteer for and fill out the Google form. Once registered, we will reach out to you when a suitable study becomes available. Your involvement plays a crucial role in advancing our understanding of the human brain, and we welcome you to be a part of our exciting journey in pushing the boundaries of scientific exploration. Who can volunteer? Unaffected Volunteers PARAM ENIGMA Anyone who has not been diagnosed with a severe mental illness, nor have any of their immediate family members. Anyone without major/severe development delays who can sit through a neuropsychology assessment and answer questions would be eligible for our assessments. Healthy elders, persons with Alzheimer’s dementia, and persons with Mild Cognitive Impairment (MCI—a stage between normal cognitive functioning and dementia) Ph.D. Theses & Dissertations | MGL NIMHANS PhD Thesis & Dissertations PhD Thesis Dissertations 2024 Constraint-Based Modeling Of Astrocyte Metabolism In Neuropsychiatric Disorders - Anirudh Chellappa, PhD 2023 Genetic and epigenetic correlates in alcohol-induced liver cirrhosis - Bhagyalakshmi MS, PhD 2022 Characterization and functional validation of Huntington’s disease modifiers influencing disease progression and manifestation - Sowmya DV, PhD 2019 Soundarya, PhD 2018 Influence of Genetic Variation on the Effect of Mood Stabilizer: A Cellular Model System Based Study - Pradip Paul, PhD ​ Lymphoblastoid cell lines as a model system to investigate Alzheimer's Disease - Somdatta Sen, PhD ​ Identification of genes involved in the phenotypes of ApoE variants and Alzheimer's disease - Aparna Ashok, PhD ​ Identification of lithium induced molecular network changes in Huntington’s disease - Dr Nikhil Ratna, PhD Molecular Genetics of Bipolar Disorder: a pharmacogenomics approach - Dr Ravi Kumar Nadella, PhD 2017 A Study of Association of ESR1, HMCN1, METTL13 and 5-HTTLPR Gene Polymorphisms in Women with Postpartum Psychosis and Genetic Correlates of Maternal-Infant Bonding - Dr Harish T, PhD 2015 Molecular genetic analysis of OCD, correlating phenotype and genotype - Reshma Taj, PhD 2013 Study of telomere length in dementias (Clinical Neuroscience) - Dr Lakshminarayanan Kota, PhD 2012 Molecular genetic study of bipolar affective disorder: A linkage based approach - Dr Ram Murthy, PhD 2011 Molecular mechanism of agonist & antagonist with 5-HT receptors, structural consequences of SNPs & evolutionary trace analysis of 5-HT receptors - Dr Padmanaban, PhD 2010 Identification of Molecular Mechanisms Underlying Psychotherapeutic Drug action and Susceptibility to Major Psychoses - Dr Shuba D, PhD 2008 Linkage & association studies to identify susceptibility loci for psychoses - Dr Kiran Kumar, PhD 2006 Molecular genetics study of major psychoses & binding density of 5HT2A receptors in platelets - Dr Odity Mukherjee, PhD 2018 Differential expression of Cathepsin B, Tissue Inhibitor of Metalloproteinases 4, Collagen 1A2, B-cell lymphoma 2(bcl-2), Bcl-2 Associated X protein (bax) & α1-Anti Trypsin genes in intracranial aneurysmal wall, Dr Gaurav Tyagi, MCh, Neurosurgery 2017 An Association Study of GRIN2B polymorphism rs 1805502 and Postpartum psychosis, Dr Sara Eraly, MD, Psychiatry ​ GSK 3-Beta Polymorphisms and associated clinical parameters in patients with Bipolar Illness, Dr Bharathram, MD, Psychiatry ​ PparG Polymorphism (PRO12ALA) in Alzheimer's dementia with diabetes: An exploratory study, Dr Abhishek Purty, MD, Psychiatry 2016 Investigating the role of one-carbon metabolism pathway in complicated alcohol withdrawal states, Dr Karishma Kulkarni, MD, Psychiatry ​ Pharmacogenetic association of glutamate transporter gene and SRI response in OCD, Dr Tulika Shukla, MD, Psychiatry ​ Lithium prophylaxis and Neurotrophic /Neuroprotective genes: an association study and gene expression analysis in patients of Bipolar disorder, Dr Ravi Kumar Nadella, MD, Psychiatry 2015 Brain development (white matter) genetic variation and risk for alcohol dependence: imaging genetics study, Dr Ramesh Jagarapu, MD, Psychiatry ​ Effect of genetic variations on temperament and cognitive function, Dr Kiran BR, MD, Psychiatry 2014 Role of Copper in Alzheimer’s Dementia- a Controlled Study, Dr Siddesh Shere, MD, Psychiatry Inbreeding in schizophrenia, Dr Suhas T, MD, Psychiatry 2013 Neurobiology of Auditory Verbal Hallucinations in Schizophrenia - An Integrated fMRI-, EEG- and Genomics-based Approach, Dr Harsha Halahalli, PhD, Psychiatry ​ Association of plasma clusterin protein with Alzheimer’s disease, Dr Kavita Nagpal, MD, Psychiatry Role of Apoe polymorphism in predicting surgical outcome in patients with cervical spondylosis and ossified posterior longitudinal ligament, Dr Tanmoy Maiti, MCh, Neurosurgery ​ Expression of Cathepsin B, K, S, and Elastin in intracranial aneurysmal walls, Dr Arun Babu, MCh, Neurosurgery 2012 Alzheimer’s Dementia: Clinical, Genetic and Diffusion Tensor Imaging study, Dr Bhavani Bagepally, PhD, Clinical Neuroscience 2011 Study of glutamate receptor gene polymorphisms in alcohol dependent patients with simple and severe withdrawal, Dr Ajit Dahale, MD, Psychiatry 2010 Association study of DRD4 polymorphisms and MPA with ADHD in Indian population, Dr C Guruprasad, MD, Psychiatry ​ Association Study of APOE gene polymorphisms & Neurodevelopmental markers in schizophrenia, Dr Abish Anthony, MD, Psychiatry ​ Association Study of APOE gene polymorphisms & Neurodevelopmental markers in bipolar disorder, Dr Avinash Waghmare, MD, Psychiatry 2009 Neuropsychological profile of individuals at–risk for Huntington’s disease, Dr. Saumya Udupa, PhD, Mental health & Social psychology ​ Study of the DAT1 gene polymorphism in severe alcohol withdrawal, Dr Brij Kishore, MD, Psychiatry ApoE4 frequency in late onset depression, Dr Suresh Kumar, MD, Psychiatry 2008 Voxel based Morphometry of brain in SCA 1, 2, & 3, Dr Gaurav Goel, DM, Neuroradiology 2007 Study of 5HTT gene polymorphism in OCD, Dr Prashant Tibrewal, MD, Psychiatry 2004 ApoE polymorphism in dementia samples, Dr. Mansoor Ali Khan, MPhil, Neuroscience 2003 Study of natural history & effect of corticosteroids, Dr Lokesh L, DM, Neurology 2000 Clinical and Genetic characterization of Huntington’s disease in an Indian population, Dr Uday Murgod, DM, Neurology Fullscreen Page | MGL NIMHANS सभी देखें इवेंट्स (2) Exploring Bipolar Disorder Through Art 30 March 2024 | 13:30 Talk by Dr. Kenneth S Kendler | Mood Disorders: History, Nosology and Current Genetic Findings 12 March 2024 | 13:30 Nimhans Campus, Lakkasandra, Laljinagar, Wilson Garden, Bengaluru, Karnataka 560029, India सभी देखें

शनि, 30 मार्च | Location is TBD Exploring Bipolar Disorder Through Art Registration is closed See other events समय और स्थान 30 मार्च 2024, 7:00 pm – 11:00 pm Location is TBD इवेंट के बारे में We're excited to announce an open call for art submissions on the occasion of the upcoming "World Bipolar Day". Celebrated each year on March 30th, on the birth anniversary of Vincent Van Gogh (who was posthumously diagnosed with bipolar disorder), World Bipolar Day encourages people to learn what bipolar disorder is - and isn't. We invite artists to submit their artwork focusing on bipolar disorder; either from a perspective of personal experience or empathy. Select submissions will be displayed at our in-person event in Bangalore (details coming soon!) and online. अधिक पढ़ें > यह इवेंट साझा करें

Welcome Updates Research Jobs Molecular Genetics Lab About Us The Molecular Genetics Laboratory (MGL) is dedicated to understanding the genetic and molecular basis of neuropsychiatric disorders. Our mission is to advance mental health and neurological care through innovative research, education, and clinical services. Located in Bangalore, India, MGL is part of the National Institute of Mental Health and Neurosciences (NIMHANS), which has been at the forefront of mental health and neuroscience research for decades. Our team comprises esteemed scientists, clinicians, and researchers committed to translating scientific discoveries into clinical applications. We focus on unraveling the complexities of brain function and behavior to improve patient outcomes and contribute to global knowledge in psychiatric genetics. Introduction New at MGL Welcome to our incoming Ph.D. batch of 2024! (L-R) Deepankan, Shrinkhala, Pannaga (Not pictured) Rashmi Celebrating 25 years of MGL and Dr Meera! New publication alert! Exploring the genetics of lithium response in bipolar disorders Dr Suhas G awarded 2024 Society of Biological Psychiatry Travel Fellowship Award Dr Bhagyalakshmi MS awarded the 2024 WFSBP Young Investigator Award New publication alert! Altered neuroepithelial morphogenesis and migration defects in iPSC-derived cerebral organoids and 2D neural stem cells in familial bipolar disorder Welcome to our incoming Ph.D. batch of 2023! (L-R) Akshaya, Mythri, Lakshana, Srividya Our Research At MGL, our research spans a wide range of areas, focusing on the genetic and molecular mechanisms underlying neuropsychiatric conditions such as schizophrenia, dementia, OCD, alcoholism, spino-cerebellar ataxia and muscular dystrophy. Our multidisciplinary approach combines clinical insights with advanced genetic methods, supported by national and international funding agencies. We collaborate with leading global institutions to enhance our research impact and develop new therapeutic strategies. Read More Do you want to participate in our research? Click here to learn more Opportunities Technical Assistant Project Nurse under the GenECT project (Kolar location) Contact

Work With Us Technical Assistant Contract Applications are invited from the eligible candidates for the vacant posts of TECHNICAL ASSISTANT under the Department of Psychiatry as mentioned below in the prescribed form from the Indian Nationals for appointment on CONTRACT BASIS. ​ Deadline: September 17, 2024 Learn More Project Nurse Contract NIMHANS is conducting WALK-IN-SELECTION for filling up the post of “Project Nurse” for the project entitled “Genetics at an extreme: an efficient genomic study of individuals with clinically severe major depression receiving ECT” funded by the NIMH-USA: National Institute of Mental Health, USA, under Dr. Biju Viswanath, Additional Professor, Department of Psychiatry & Principal Investigator, NIMHANS, Bengaluru. ​ Date & Time: September 11, 2024 on at 10:00 A.M. Learn More Internship Opportunities Explore the dynamic realm of neuroscience and psychiatric research with internship opportunities at MGL-NIMHANS. Gain invaluable hands-on experience, delve into cutting-edge research, and be part of a team shaping the future of brain science. Internship opportunities are available on a rolling basis. Write to us with a statement of interest and your CV, and we will reach out to you if there are any available positions. Sign Up

Publications

Participate in Our Research Be a part of our groundbreaking research initiatives by volunteering! Our research delves into understanding the complexities behind severe psychiatric illnesses. Our studies may involve - non-invasive methods like EEG recordings, where sensors are placed on the scalp to capture brainwave activity MRI brain scans simple measurements of button-press responses or eye movements blood sample which will be used for genetic and stem cell studies For more information about which studies are currently recruiting volunteers, click the project names to read about the work and go through the hyperlinked information & consent forms listed below. If you are eager to participate as a research volunteer, click the project you wish to volunteer for and fill out the Google form. Once registered, we will reach out to you when a suitable study becomes available. Your involvement plays a crucial role in advancing our understanding of the human brain, and we welcome you to be a part of our exciting journey in pushing the boundaries of scientific exploration. Who can volunteer? Unaffected Volunteers PARAM ENIGMA Anyone who has not been diagnosed with a severe mental illness, nor have any of their immediate family members. Anyone without major/severe development delays who can sit through a neuropsychology assessment and answer questions would be eligible for our assessments. Healthy elders, persons with Alzheimer’s dementia, and persons with Mild Cognitive Impairment (MCI—a stage between normal cognitive functioning and dementia)

PhD Thesis & Dissertations PhD Thesis Dissertations 2024 Constraint-Based Modeling Of Astrocyte Metabolism In Neuropsychiatric Disorders - Anirudh Chellappa, PhD 2023 Genetic and epigenetic correlates in alcohol-induced liver cirrhosis - Bhagyalakshmi MS, PhD 2022 Characterization and functional validation of Huntington’s disease modifiers influencing disease progression and manifestation - Sowmya DV, PhD 2019 Soundarya, PhD 2018 Influence of Genetic Variation on the Effect of Mood Stabilizer: A Cellular Model System Based Study - Pradip Paul, PhD ​ Lymphoblastoid cell lines as a model system to investigate Alzheimer's Disease - Somdatta Sen, PhD ​ Identification of genes involved in the phenotypes of ApoE variants and Alzheimer's disease - Aparna Ashok, PhD ​ Identification of lithium induced molecular network changes in Huntington’s disease - Dr Nikhil Ratna, PhD Molecular Genetics of Bipolar Disorder: a pharmacogenomics approach - Dr Ravi Kumar Nadella, PhD 2017 A Study of Association of ESR1, HMCN1, METTL13 and 5-HTTLPR Gene Polymorphisms in Women with Postpartum Psychosis and Genetic Correlates of Maternal-Infant Bonding - Dr Harish T, PhD 2015 Molecular genetic analysis of OCD, correlating phenotype and genotype - Reshma Taj, PhD 2013 Study of telomere length in dementias (Clinical Neuroscience) - Dr Lakshminarayanan Kota, PhD 2012 Molecular genetic study of bipolar affective disorder: A linkage based approach - Dr Ram Murthy, PhD 2011 Molecular mechanism of agonist & antagonist with 5-HT receptors, structural consequences of SNPs & evolutionary trace analysis of 5-HT receptors - Dr Padmanaban, PhD 2010 Identification of Molecular Mechanisms Underlying Psychotherapeutic Drug action and Susceptibility to Major Psychoses - Dr Shuba D, PhD 2008 Linkage & association studies to identify susceptibility loci for psychoses - Dr Kiran Kumar, PhD 2006 Molecular genetics study of major psychoses & binding density of 5HT2A receptors in platelets - Dr Odity Mukherjee, PhD 2018 Differential expression of Cathepsin B, Tissue Inhibitor of Metalloproteinases 4, Collagen 1A2, B-cell lymphoma 2(bcl-2), Bcl-2 Associated X protein (bax) & α1-Anti Trypsin genes in intracranial aneurysmal wall, Dr Gaurav Tyagi, MCh, Neurosurgery 2017 An Association Study of GRIN2B polymorphism rs 1805502 and Postpartum psychosis, Dr Sara Eraly, MD, Psychiatry ​ GSK 3-Beta Polymorphisms and associated clinical parameters in patients with Bipolar Illness, Dr Bharathram, MD, Psychiatry ​ PparG Polymorphism (PRO12ALA) in Alzheimer's dementia with diabetes: An exploratory study, Dr Abhishek Purty, MD, Psychiatry 2016 Investigating the role of one-carbon metabolism pathway in complicated alcohol withdrawal states, Dr Karishma Kulkarni, MD, Psychiatry ​ Pharmacogenetic association of glutamate transporter gene and SRI response in OCD, Dr Tulika Shukla, MD, Psychiatry ​ Lithium prophylaxis and Neurotrophic /Neuroprotective genes: an association study and gene expression analysis in patients of Bipolar disorder, Dr Ravi Kumar Nadella, MD, Psychiatry 2015 Brain development (white matter) genetic variation and risk for alcohol dependence: imaging genetics study, Dr Ramesh Jagarapu, MD, Psychiatry ​ Effect of genetic variations on temperament and cognitive function, Dr Kiran BR, MD, Psychiatry 2014 Role of Copper in Alzheimer’s Dementia- a Controlled Study, Dr Siddesh Shere, MD, Psychiatry Inbreeding in schizophrenia, Dr Suhas T, MD, Psychiatry 2013 Neurobiology of Auditory Verbal Hallucinations in Schizophrenia - An Integrated fMRI-, EEG- and Genomics-based Approach, Dr Harsha Halahalli, PhD, Psychiatry ​ Association of plasma clusterin protein with Alzheimer’s disease, Dr Kavita Nagpal, MD, Psychiatry Role of Apoe polymorphism in predicting surgical outcome in patients with cervical spondylosis and ossified posterior longitudinal ligament, Dr Tanmoy Maiti, MCh, Neurosurgery ​ Expression of Cathepsin B, K, S, and Elastin in intracranial aneurysmal walls, Dr Arun Babu, MCh, Neurosurgery 2012 Alzheimer’s Dementia: Clinical, Genetic and Diffusion Tensor Imaging study, Dr Bhavani Bagepally, PhD, Clinical Neuroscience 2011 Study of glutamate receptor gene polymorphisms in alcohol dependent patients with simple and severe withdrawal, Dr Ajit Dahale, MD, Psychiatry 2010 Association study of DRD4 polymorphisms and MPA with ADHD in Indian population, Dr C Guruprasad, MD, Psychiatry ​ Association Study of APOE gene polymorphisms & Neurodevelopmental markers in schizophrenia, Dr Abish Anthony, MD, Psychiatry ​ Association Study of APOE gene polymorphisms & Neurodevelopmental markers in bipolar disorder, Dr Avinash Waghmare, MD, Psychiatry 2009 Neuropsychological profile of individuals at–risk for Huntington’s disease, Dr. Saumya Udupa, PhD, Mental health & Social psychology ​ Study of the DAT1 gene polymorphism in severe alcohol withdrawal, Dr Brij Kishore, MD, Psychiatry ApoE4 frequency in late onset depression, Dr Suresh Kumar, MD, Psychiatry 2008 Voxel based Morphometry of brain in SCA 1, 2, & 3, Dr Gaurav Goel, DM, Neuroradiology 2007 Study of 5HTT gene polymorphism in OCD, Dr Prashant Tibrewal, MD, Psychiatry 2004 ApoE polymorphism in dementia samples, Dr. Mansoor Ali Khan, MPhil, Neuroscience 2003 Study of natural history & effect of corticosteroids, Dr Lokesh L, DM, Neurology 2000 Clinical and Genetic characterization of Huntington’s disease in an Indian population, Dr Uday Murgod, DM, Neurology